Optimal Differential Profilometry

Calcium Phosphate - “Beyond Nano Size”

Thick Oxide Layer

Hydrophilic Surface Increases Wettability

Site-Specific Surface Modification

 

Changing the Nature of Healing

Numerous scientific papers have been published on OSSEAN®. They report the remarkable performance of this surface compared to others, particularly immediately after implant placement and during the initial phase of healing. The very nature of the healing chain has been reported to be changed and shortened*.

 

Compressing the Healing Process

The most critical phase of implant treatment occurs from the moment an implant is surgically placed, through the first weeks of initial healing. It is in this period when most complications and/or adverse effects occur. This juncture also sets the stage for ongoing and long-­term future implant success. Naturally, the importance of shortening this time by compressing the healing process  is crucial*.

 

Documented “in-vivo” Study

Furthermore, this early accelerated healing process has been documented in “in-vivo” in  a bone histological, gene expression, and nanomechanical study. The OSSEAN® surface was shown to play a critical role at the DNA level by favorably enhancing osteoblasts formation and accelerating the mineralization on the newly formed bone*.

 

Robotically Micro Blasted

Each Intra-Lock® implant is Robotically Micro-Blasted in a clean room environment for precise control. Robotic sequencing and

differential is treatment is utilized to preserve the cutting groove geometry (sharpness) and permit each region of the implant to obtain optimal topography and surface roughness*.­­­

 

Multi-Phase Cleaning and

Surface Treatment

Additional procedures derived from the semiconductor industry and refined for bio-medical applications ensure a clean surface. OSSEAN® Surface is exceptionally free from contaminants as confirmed by XPS-ESCA (Electron Spectroscopy for Chemical Analysis).

Calcium Phosphate in

Molecular Fusion

Multi-Process Cleaning

Keeps Surface Free from

Contaminants

Robotic Micro-Blasting Preserves

Cutting Edge Geometry

Cellular Level -

Enhanced Osteoblast

Attachment

Molecular Level -

Improved Fibrin

Attachment

Thick Oxide Layer

Hydrophilic Surface

It's in the Details...

Take a Closer Look...

Micro-Nano Fractal Topography

AFM: Atomic Force Microscopy

OSSEAN® Surface profilometry is well characterized with Atomic Force Microscopy, showing explicit details of its complex surface at various levels of ­­observations*.

 

This image shows a surface of 20µm x 20µm.

 ( Mouse Over Image to Zoom )

OSSEAN® Surface structure is engineered to increase host-to-implant biocompatibility and biomechanical response*. It is characterized by having a surface topography that is similar at all levels of magnification, from the surface to the nanoscale level. The repetitive nature of this surface is defined as one that is “fractal” in nature. As with a set of Russian dolls, the structure when viewed at different levels of magnification has the same basic characteristics.

 

The surface beyond the nanometric level displays an ideal surface for fibrin ­­attachment. At the micrometric level, the pattern is appropriate for platelet deposition*. Under lower magnification, the pattern shows receptor sites that encourage the growth of osteoblasts*.

Calcium Phosphate – Molecular Impregnation

AUGER Spectroscopy:

An electron beam of 15nanometers diameter is shot at various locations on the Ossean® Surface. The edge, bottom and an intermediate location of the surface all show peaks of Ca and P.­­­ They are combined in a Calcium Phosphate chemical state as confirmed by the XPS-ESCA.

 

( Mouse Over Image to Zoom )

When viewed at a maximum SEM resolution (200,000X), OSSEAN® Surface is free of any particles. However, when examined under Auger X-Ray Spectroscopy, calcium phosphate molecules (more than a thousand times smaller than nano particles) are revealed. They are present in the Titanium oxide layer as molecules (Molecular Impregnation), well beyond the nanometric level. These molecules have a greater binding energy than larger particles of calcium phosphate. In addition to extreme stability, the calcium phosphate retains its bioactive properties *­­­.

Nanometer-scale features on

micrometer-scale surface texturing:

A bone histological, gene expression,

and nanomechanical study

Osseointegration: Hierarchical

designing encompassing the

macrometer, micrometer, and

nanometer length scales

 

*Ossean References:

1.  Nanometer-scale features onmicrometer-scale surface texturing: A bone histological, gene expression, and nano mechanical study. Paulo G. Coelho, Tadahiro Takayama, Daniel Yoo, Ryo Jimbo, Sanjay Karunagaran, Nick Tovar, Malvin N. Janal, Seiichi Yamano.

 

2.  Osseointegration: Hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales Paulo G. Coelhoa, Ryo Jimbod, Nick Tovar,

Estevam A. Bonfantee http://dx.doi.org/10.1016/j.dental.2014.10.000109-5641/© 2014 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

 

3.  Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 1: description of the Implant Surface Identification Standard (ISIS) codification system. POSEIDO. 2014;2(1):7-22.

 

4.  Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 2: anodized and Titanium Plasma-Sprayed (TPS) surfaces (Group 1, metallurgy modification). David M. Dohan Ehrenfest, Marco Del Corso, Byung-Soo Kang, Philippe Leclercq, Ziv Mazor, Robert A. Horowitz, Philippe Russe, Hee-Kyun Oh, De-Rong Zou, Jamil Awad Shibli, Hom-Lay Wang, Jean-Pierre Bernard, and Gilberto Sammartino.  POSEIDO. 2014;2(1):23-35.

 

5.  Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 3: sand-blasted/acid-etched (SLA type) and related surfaces (Group 2A, main subtractive process). David M. Dohan Ehrenfest, Marco Del Corso, Byung-Soo Kang, Philippe Leclercq, Ziv Mazor, Robert A. Horowitz.

 

6.  Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 4: Resorbable Blasting Media (RBM), Dual Acid-Etched (DAE), Subtractive Impregnated Micro/Nanotextured (SIMN) and related surfaces (Group 2B, other subtractive process). David M. Dohan Ehrenfest, Marco Del Corso, Byung-Soo Kang, Philippe Leclercq, Ziv Mazor, Robert A. Horowitz, Philippe Russe, Hee-Kyun Oh, De-Rong Zou, Jamil Awad Shibli, Hom-Lay Wang, Jean-Pierre Bernard, and Gilberto Sammartino.  POSEIDO. 2014;2(1):57-79.

 

7.  Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 5: chemically coated surfaces (Group 3, coating) and implant collar surfaces (Group 4, collar). David M. Dohan Ehrenfest, Marco Del Corso, Byung-Soo Kang, Philippe Leclercq, Ziv Mazor, Robert A. Horowitz, Philippe Russe, Hee-Kyun Oh, De-Rong Zou, Jamil Awad Shibli, Hom-Lay Wang, Jean-Pierre Bernard, and Gilbert Sammartino.  POSEIDO. 2014;2(1):81- 104.

 

8.  Fractal patterns applied to implant surface: definitions and perspectives David Marcel Dohan Ehrenfest, DDS, MS, PhD1 University of Gothenburg, Department of Biomaterials, University of Gothenburg J Oral Implantol. 2011 Oct;37(5):506-9. Epub 2011 Jun 13.

 

9.  Identification card and codification of the chemical and morphological characteristics of 14 dental implant surfaces. David Marcel Dohan Ehrenfest, DDS, MS, PhD1, Lydia Vazquez, Yeong-Joon Park, Gilberto Sammartino, and Jean-Pierre Bernard Chonnam National University School of Dentistry, LoB5 unit, School of Dentistry, Gwangju, South Korea - ­Journal of Oral Implantology: October 2011, Vol. 37, No. 5, pp. 525-542. doi: http://dx.doi.org/10.1563/AAID-JOI-D-11-00080

 

10.  Comparative Analysis of Early Bone Bonding Using Various Surface Treatments. R.J. Miller, P. Coelho, C. Marin, R. Granato, M. Suzuki, J. Gil Delray Beach, FL.

2010, Academy of Osseointegration, Annual Meeting, P202

 

11.  Physico/Chemical Characterization­­- and Biomechanical Evaluation of Three Different Grit-Blasting and Acid-Etching Surface Treatments. An Experimental Study in Dogs. G.S. Bernardes, R.Granato, M. Suzuki, J.N. Gil, C. Marin, P.G. Coelho New York, NY, 2009, Academy of Osseointegration, Annual Meeting, P180

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