Scientific Literature

Abstract

 

Among the multiple factors that determine the achievement and the preservation of the osseointegration, physicochemical properties of the implant surface play a primary role Within milliseconds after exposure, an implant’s surface is covered with protein molecules absorbed from the surrounding environment.

 

The nature, thickness, stability, and other characteristics of this protein layer depend in large measure on the characteristics of the surface. The structural details of the cells’ body that determine the achievement and preservation of a successful implant are the result of the stimuli that come from the implant surface.

 

Keeping these considerations in mind, an evaluation of the adhesion and proliferation of the SaOs-2 Human Osteoblast on two comparative surfaces have been carried out over varying time periods.

 

Phase 1: Superficial topographical characterization through X-ray Spectroscopy (XPS)

 

Phase 2: Comparing Osteoblasts’ adhesion to the Ossean? surface Vs the Classic Blasted and acid etched surface.

 

Phase 3: Comparing Alkaline Phosphatase (ALP) activity on those two surfaces has been closely evaluated of a various time periods.

 

This enzyme is an early indicator of the osteoblastic differentiation. At the time the production of ALP on the part of human mesenchymal cells have been evaluated. These are capable of differentiating in at least three different phenotypes: the adipogenic, chondrogenic, and osteogenic line. It is however still not clear which factors determind the preferential differentiation towards a particular line. The objective of this research is try to understand if the surface per se’ and/or the presence of adequate chemical stimuli could induce the desired differentiation.

 

Conclusion: The results of the research have demonstrated an advanced avtivity of the Alkaline Phosphatise Enzyme (ALP) on the Ossean? surface during the first days. The Ossean? surface shows, with statistically significant differential, a higher enzymatic activity compared to the Classic surface in the first phase of healing.

Human Osteoblast growth on a Novel Implant Surface Vs a classic Blasted and Acid Etched Surface.

 

 

2009, Academy of Osseointegration, Annual Meeting, CI-7

Implant

Surface: 14

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